Correlation between septal midwall late gadolinium enhancement on CMR and conduction delay on ECG in patients with nonischemic dilated cardiomyopathy

Publication date: February 2020Source: IJC Heart &Vasculature, Volume 26Author(s): Marthe A.J. Becker, Cornelis P. Allaart, Alwin Zweerink, Jan H. Cornel, Peter M. van de Ven, Albert C. van Rossum, Tjeerd GermansAbstractBackgroundSeptal midwall late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) is a characteristic finding in nonischemic dilated cardiomyopathy (DCM) and is associated with adverse cardiac events. QRS-prolongation in DCM is also frequently present and a predictor of arrhythmic events and mortality. Since the His-Purkinje fibres are located in the interventricular septum, QRS-prolongation may directly result from septal fibrosis, visualized by LGE. Our aim was to study the correlation of the presence and extent of septal midwall LGE and QRS-duration.MethodsDCM-patients with left ventricular (LV) dysfunction (LVEF 
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research

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Ventricular tachycardia (VT) is a potentially life-threatening heart rhythm disorder based on a reentry circuit within a ventricular substrate which may degenerate into ventricular fibrillation and cardiac arrest. Substrate-related VT can occur due to coronary artery disease or other structural cardiomyopathies, including non-ischemic dilated cardiomyopathy (DCM) [1]. The first-line and only life-saving treatment of hemodynamically unstable VTs without a reversible cause according to current guidelines is the implantation of a implantable cardioverter-defibrillator (ICD) [2].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: First in Human Source Type: research
Publication date: Available online 31 December 2019Source: Canadian Journal of CardiologyAuthor(s): Paul Dorian, Andrew T. Yan, Kim Connelly
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
This study further enforces the association betweenBAG3 gene and CMT disease, indicating thatBAG3 should be considered in the genetic testing for CMT. The p.Pro209Ser mutation with different ethnic origins might be another hotspot mutation ofBAG3. MRI is helpful to detect accurate extent of muscle involvement.
Source: Journal of Neurology - Category: Neurology Source Type: research
CONCLUSION: LGE presence independently predicted adverse clinical events in Asian patients with DCM. Routine use of CMR imaging to characterise the myocardial substrate is recommended for enhanced risk stratification and should strongly influence clinical management. PMID: 31820004 [PubMed - as supplied by publisher]
Source: Singapore Medical Journal - Category: General Medicine Authors: Tags: Singapore Med J Source Type: research
CONCLUSIONS: The high variability of morphological findings and clinical manifestations of LVNC results in frequent overlooking of this disorder. Therefore, it is important to make the specialists more familiar with this condition and its pathology. Magnetic resonance imaging represents a conducive method to make correct diagnosis of LVNC under several specific conditions, particularly in case of non-conclusive echocardiographic finding. PMID: 31785212 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
In this study we aimed to investigate left atrial (LA) function, measured from routine cine cardiovascular magnetic resonance imaging, to determine its value for the prediction of sudden cardiac death (SCD) or appropriate implantable cardioverter defibrillator (ICD) shock in patients who received primary prevention ICD implantation.MethodsWe studied 203 patients with ischemic or idiopathic nonischemic dilated cardiomyopathy who underwent cardiovascular magnetic resonance imaging before primary prevention ICD implantation. LA volumes were measured at end-diastole and end-systole from 4- and 2-chamber cine images, and LA emp...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Abstract BACKGROUND: Vici syndrome is a neurodevelopmental disorder of the autophagy pathway. Almost all cases reported have the cardinal features of agenesis of corpus callosum, cataract, cardiomyopathy, immunodeficiency and hypopigmentation. CASE CHARACTERISTICS: 8-month-old boy with developmental delay, myoclonic jerks, repeated respiratory infections, coarse facial features, cataract and hypopigmented hair. Echocardiography revealed dilated cardiomyopathy and magnetic resonance imaging of brain suggested agenesis of corpus callosum. Exome sequencing detected a novel homozygous nonsense mutation in the EPG...
Source: Indian Pediatrics - Category: Pediatrics Authors: Tags: Indian Pediatr Source Type: research
Iris Lavon1,2†, Coral Heli1†, Livnat Brill1, Hanna Charbit1,2 and Adi Vaknin-Dembinsky1* 1Department of Neurology and Laboratory of Neuroimmunology, and the Agnes-Ginges Center for Neurogenetics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel 2Leslie and Michael Gaffin Center for Neuro-Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel Background: The clinical course of multiple sclerosis ranges from benign with little disease progression and minimal disability, to severe disease requiring intensive medical treatment. There are no reliable circulating biomarkers fo...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: The diagnosis of acute myocarditis still remains a great challenge, despite advances related to new diagnostic procedures. Endomyocardial biopsy, an invasive diagnostic tool that is not always usually available in clinical practice, still remains the standard diagnostic technique. Due to the potential evolution of acute myocarditis, identifying new parameters that may allow an early selection of patients with great risk of evolution toward myocardial fibrosis and dilated cardiomyopathy may be a field of great interest for future studies.
Source: American Journal of Therapeutics - Category: Drugs & Pharmacology Tags: Systematic Reviews Source Type: research
Discussion Barth syndrome is characterized by a dilated cardiomyopathy, proximal skeletal muscle weakness, neutropenia and short stature that usually presents at birth or soon after. It is a rare X-linked recessive disease process caused by mutations in the TAZ gene. The TAZ gene codes for tafazzin which alters cardiolipin in mitochondria. Characteristic facies can be seen especially in infancy including a tall and broad forehead, prominent chin and full cheeks, larger ears, and deep-set eyes. Most patients present at birth or soon afterwards but some may not until later in life. Life expectancy is reduced with many childr...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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