In situ nuclear DNA methylation in dilated cardiomyopathy: an endomyocardial biopsy study

ConclusionsThe present study revealed increased nuclear DNA methylation in cardiomyocytes, but not other cell types, from DCM hearts, with predominant localization in the heterochromatin. Its significant relations with LV functional and remodelling parameters imply a pathophysiological significance of DNA methylation in heart failure.

Source: ESC Heart Failure - January 22, 2020 Category: Cardiology Authors: Takatomo Watanabe, Hideshi Okada, Hiromitsu Kanamori, Nagisa Miyazaki, Akiko Tsujimoto, Chihiro Takada, Kodai Suzuki, Genki Naruse, Akihiro Yoshida, Takahide Nawa, Toshiki Tanaka, Masanori Kawasaki, Hiroyasu Ito, Shinji Ogura, Hiroyuki Okura Tags: Original Research Article Source Type: research