Circulating neuregulin1 ‐β in heart failure with preserved and reduced left ventricular ejection fraction

ConclusionsNeuregulin1 ‐β was reduced in HFpEF and further reduced in HFrEF. The opposing relationships of NRG1‐β with outcomes in non‐ischaemic HFpEF compared with HFrEF and ischaemic HFpEF may indicate compensatory increases of cardioprotective NRG1‐β from microvascular endothelial dysfunction in the former ( non‐ischaemic HFpEF), but this compensatory mechanism is overwhelmed by the presence of ischaemia in the latter (HFrEF and ischaemic HFpEF).

https://onlinelibrary.wiley.com/doi/abs/10.1002/ehf2.12615?af=R

Source: ESC Heart Failure - January 23, 2020 Category: Cardiology Authors: Camilla Hage, Eva W ärdell, Cecilia Linde, Erwan Donal, Carolyn S.P. Lam, Claude Daubert, Lars H. Lund, Agneta Månsson‐Broberg Tags: Original Research Article Source Type: research