Microbiota and alcohol use disorder: are psychobiotics a novel therapeutic strategy?

Microbiota and alcohol use disorder: are psychobiotics a novel therapeutic strategy? Curr Pharm Des. 2020 Jan 22;: Authors: Rodriguez-Gonzalez A, Orio L Abstract In recent years, there has been an exciting focus of research attempting to understand neuropsychiatric disorders from a holistic perspective in order to determine the role of gut microbiota in the aetiology and pathogenesis of such disorders. Thus, the possible therapeutic benefits of targeting gut microbiota are being explored for conditions such as stress, depression or schizophrenia. Growing evidence indicates that there is a bidirectional communication between gut microbiota and the brain that has an effect on normal CNS functioning and behavioural responses. Alcohol abuse damages the gastrointestinal tract, alters gut microbiota and induces neuroinflammation and cognitive decline. The relationship between alcohol abuse and hypothalamic-pituitary-adrenal axis activation, inflammation and immune regulation has been well documented. In this review we explore the connection between microbiota, brain function and behaviour, as well as the mechanisms through which alcohol induces microbiota dysbiosis and intestinal barrier dysfunction. Finally, we propose the study of psychobiotics as a novel pharmaceutical strategy to treat alcohol use disorders. PMID: 31969090 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research

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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic General Medications Not Crazy Podcast Source Type: blogs
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Source: The International Journal of Social Psychiatry - Category: Psychiatry Authors: Tags: Int J Soc Psychiatry Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Men's Issues Psychiatry Psychology Living With Schizophrenia Mental Disorder Mental Health Mental Illness Symptoms Of Schizophrenia Source Type: blogs
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Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Authors: Takeuchi T, Okumura Y, Ichikura K Abstract The use of alcohol or drug(s) prior to self-injury is a possible inducing factor for suicidal self-injuries among patients with adjustment disorder. We analyzed the cases of 175 individuals who were admitted to the intensive care unit (ICU) of Tokyo Medical and Dental University Medical Hospital for suicidal self-injury to determine whether alcohol consumption or an excessive use of prescribed psychotropic medications prior to self-injury is more common in patients with adjustment disorder. During a 7-year period (July 2006 to June 2013) following their deliberate...
Source: Acta Medica Okayama - Category: General Medicine Tags: Acta Med Okayama Source Type: research
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Source: Palliative Medicine - Category: Palliative Care Authors: Tags: Palliat Med Source Type: research
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Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
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