NLRP3 inflammasome mediates M1 macrophage polarization and IL-1 β production in inflammatory root resorption.

CONCLUSIONS: In periodontal tissues, hPDLCs stimulated by force promoted M1 macrophage polarization and increased IL-1β production by activating NLRP3 inflammasome in M1 macrophages, thus initiating the occurrence of RR.
PMID: 31976565 [PubMed - as supplied by publisher]

Source: Journal of Clinical Periodontology - January 23, 2020 Category: Dentistry Authors: Zhang J, Liu X, Wan C, Liu Y, Wang Y, Meng C, Zhang Y, Jiang C Tags: J Clin Periodontol Source Type: research