Fatigue in myotonic dystrophy type 1: a seven-year prospective study.

Fatigue in myotonic dystrophy type 1: a seven-year prospective study. Acta Myol. 2019 Dec;38(4):239-244 Authors: Peric S, Bjelica B, Bozovic I, Pesovic J, Paunic T, Banovic M, Brkusanin M, Aleksic K, Basta I, Pavicevic DS, Stojanovic VR Abstract Objectives: Cross-sectional studies reported fatigue in 50-90% of patients with myotonic dystrophy type 1 (DM1). The aim of this research was to assess frequency of fatigue in DM1 patients during a seven-year period. Materials and methods: Study included 64 DM1 patients at baseline (50% males, age 42 ± 12 years), and 38 after seven years. Following scales were used: Muscular Impairment Rating Scale (MIRS), Fatigue Severity Scale (FSS, score equal to or greater than 36 indicates significant fatigue), and Daytime Sleepiness Scale (DSS, score of more than six is considered significant). Results: At baseline, 54% of DM1 patients had fatigue and 46% had excessive daytime sleepiness (EDS). Ten (32%) patients with fatigue had no EDS. At the baseline, patients with fatigue were older, were more likely to had adult-onset DM1, worse MIRS and DSS compared to the patients without fatigue. After seven years, FSS score increased (34 ± 15 vs 48 14, p
Source: Acta Myologica - Category: Neurology Tags: Acta Myol Source Type: research

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Source: Andrology - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
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Source: Frontiers in Physiology - Category: Physiology Source Type: research
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Source: Frontiers in Physiology - Category: Physiology Source Type: research
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Source: Journal of Neurology - Category: Neurology Source Type: research
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Source: Journal of Neurology - Category: Neurology Source Type: research
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Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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Source: Journal of Thermal Biology - Category: Biology Source Type: research
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