“Oxygen in the neonatal period: oxidative stress, oxygen load and epigenetic changes.”
Preterm infants frequently require positive pressure ventilation and oxygen supplementation in the first minutes after birth. It has been shown that the amount of oxygen provided during stabilization, the oxygen load, if excessive may cause hyperoxia, and oxidative damage to DNA. Epidemiologic studies have associated supplementation with pure oxygen in the first minutes after birth with childhood cancer. Recent studies have shown that the amount of oxygen supplemented to preterm infants after birth modifies the epigenome.
Source: Seminars in Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Sheila Lorente-Pozo, Anna Parra-Llorca, Inmaculada Lara-Cant ón, Alvaro Solaz, José Luis García-Jiménez, Federico V. Pallardó, Máximo Vento Source Type: research
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