Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis

Androgen receptor targeted therapies have emerged as an effective tool to manage advanced prostate cancer (PCa). Nevertheless, frequent occurrence of therapy resistance represents a major challenge in the clin...
Source: Cell Communication and Signaling - Category: Molecular Biology Authors: Tags: Research Source Type: research

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The study couldn't prove cause and effect, but it found that statins, taken alone or with metformin, did seem associated with an increase in survival.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Source: Fertility News - Doctors Lounge - Category: Reproduction Medicine Tags: Cardiology, Oncology, Pharmacy, Reproductive Medicine, Diabetes, News, Source Type: news
FRIDAY, Feb. 14, 2020 -- Drugs that many men with prostate cancer might already be taking -- cholesterol-lowering statins -- may help extend their survival if they have a " high-risk " form of the disease, new research suggests. High-risk patients...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Title: Cholesterol Drugs Might Help Curb 'High-Risk' Prostate CancersCategory: Health NewsCreated: 2/14/2020 12:00:00 AMLast Editorial Review: 2/14/2020 12:00:00 AM
Source: MedicineNet Cancer General - Category: Cancer & Oncology Source Type: news
ConclusionsStatin use alone or in combination with metformin was associated with lower all ‐cause and PCa mortality among high‐risk patients, particularly in post‐diagnostic settings; further studies are warranted.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
(Thomas Jefferson University) Statin use alone or with metformin is associated with lower prostate cancer mortality from all causes, among high-risk patients.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Prostate Cancer and Prostatic Diseases, Published online: 06 February 2020; doi:10.1038/s41391-020-0207-5Associations among statins, preventive care, and prostate cancer mortality
Source: Prostate Cancer and Prostatic Diseases - Category: Urology & Nephrology Authors: Source Type: research
Telephone intervention linked to rise in men ’s vegetable consumption but not to drop in risk of progression Related items fromOnMedica Less regular PSA screening puts men at risk NICE guidance delays hinder good diabetes care Population weight control best for cutting diabetes prevalence Starting statins not beneficial in many older adults NHS must hold CCGs accountable for poor diabetes care
Source: OnMedica Latest News - Category: UK Health Source Type: news
ConclusionMetformin and statins were not associated with BFFS or DFFS improvement in our analysis. However, the small number of patients treated with these drugs limits the reliability of the results and prospective studies are needed.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Authors: Wang FM, Zhang Y Abstract Background: The effect of lipoprotein(a) (Lp(a)) on prostate cancer (PCa) is unclear. The aim of this study was to investigate the association between serum Lp(a) levels and clinicopathological features in patients with PCa. Methods: A total of 376 consecutive pathologically diagnosed PCa patients were enrolled and were classified as a low-intermediate-risk group or a high-risk group. The association of Lp(a) and the other lipid parameters including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides ...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
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