Sexually Dimorphic Urethral Activity in Response to Pharmacological Activation of 5-HT1A Receptors in the Rat.

In this study, we examined the possibility that 5-HT1A receptors may underlie sexually dimorphic mechanisms affecting regulation of urethral functions in anesthetized rats. Simultaneous recordings of the intravesical pressure under isovolumetric conditions (isovolumetric IVP), external urethral sphincter-electromyography (EUS-EMG), and urethral perfusion pressure (UPP) were used to examine the effects of a 5-HT1A receptor agonist (8-OH-DPAT) and antagonist (WAY-100635) on bladder and urethral functions. This research also evaluated the effects of 8-OH-DPAT and α-bungarotoxin (a neuromuscular blockade agent) on urethral continence using leak point pressure (LPP) testing, and the distribution of 5-HT1A receptors in the lower urinary tract was assessed by immunohistochemistry (IHC). The serotonergic mechanism that controls the urinary bladder and EUS-EMG activity showed no significant sexual difference, but urethral activity in UPP and LPP values exhibited some sexual differences. 8-OH-DPAT enhanced urethral pressure during continence in rats of both sexes, but the drug elevated the pressure during voiding in males and reduced it in females. The distribution of 5-HT1A receptors in the spinal cord also showed some sexual differences. The present study contributes to our understanding of the role of 5-HT1A receptors in physiological and IHC properties of urethral smooth muscle in rats of different sexes. These findings may be a basis for the future development of pharmacothe...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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Conclusion: We reported two cases of bladder agenesis, and for the first time, we have performed neobladder creation surgery using the cecum and ascending colon. One-year follow-up did not reveal any complications. PMID: 33029134 [PubMed]
Source: Advances in Urology - Category: Urology & Nephrology Tags: Adv Urol Source Type: research
Kathy Siggins and Lynda Everman are thrilled to share the welcome news that the US Postal Service has reinstated sales of the Alzheimer’s Disease Research Semipostal Stamp effective October 5, 2020. It is now available for purchase at most post offices and online at https://store.usps.com/store/product/buy-stamps/alzheimers-S_564204, and by phone at 1-800 STAMP-24. Before it was withdrawn in November 2019, over 8.2 million stamps were sold during its two-year run raising $1,061,777 for NIH-supported research to advance better treatments, prevention, and one day, a cure of Alzheimer’s and related dementias. The ...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
In this study, we have evaluated the efficiency of fractional carbon dioxide laser in the treatment of vaginal laxity and urinary incontinence. Thirty patients with vaginal laxity, sexual dysfunction and urinary incontinence complaints were treated with fractional carbon dioxide laser. Results were evaluated with patient questionnaires relating to comfort during the procedure and general satisfaction following the procedure. In the survey regarding comfort during the procedure, 90% (n:27) of the patients reported that they were comfortable during the procedure. The survey on the level of general satisfaction six months fol...
Source: Journal of Plastic Surgery and Hand Surgery - Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research
Conclusion: Partial surgical extirpation is a reasonable treatment for long segment intramedullary dermoid cysts, particularly when the tumor capsule is adherent to critical adjacent neural tissues. PMID: 33024606 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Conclusion: Teratomas should be considered among the differential diagnostic considerations for intramedullary spinal cord lesions. Although gross total resection is preferred, these lesions have a low recurrence rate, and therefore, partial removal is also valid, where lesions are densely adherent to adjacent neural structures. PMID: 33024604 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Many women suffer from incontinence during or after pregnancy, and pelvic muscle exercises are one way to help. An updated Cochrane Review in May 2020 presents the evidence from 46 trials and we asked two of the authors, Stephanie Woodley and Jean Hay-Smith from the University of Otago in New Zealand, to tell us about the latest findings. Here ’s Stephanie to begin.
Source: Podcasts from The Cochrane Library - Category: General Medicine Authors: Source Type: podcasts
Conclusions: Early evidence suggested the partial-gland HIFU was safer than whole-gland HIFU, and they had similar oncological outcomes. More prospective randomized controlled trials of whole-gland and partial-gland HIFU for PCa was needed.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Photo credit Matteo Vistocco One of the most commonly asked questions about cognitive issues is “Is it Alzheimer’s or dementia?” The short answer is, Alzheimer’s is one type of dementia. According to the Alzheimer’s Association, “Dementia is a general term for loss of memory and other mental abilities severe enough to interfere with daily life. It is caused by physical changes in the brain.” View this slideshow on HealthCentral for more insight into the confusion between the words "Alzheimer's" and "dementia." Purchase Minding Our Elders: Caregive...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
AbstractPurposeAnalysis of quality of life changes after radiotherapy with focus on the impact of time after treatment and prescription dose.MethodsConsecutive patients were treated with doses from 70.2/1.8  Gy (n = 206) to 72/1.8–2.0 Gy (n = 176) in a single centre and surveyed using the Expanded Prostate Cancer Index Composite questionnaire.ResultsUrinary and bowel bother scores decreased 1 / 3 / 6 points and 7 / 7 / 9 points on average 1 / 5 / 10  years after RT in comparison to baseline scores. The rate of urinary (need of pads in 8% vs. 15% before vs. 10 years...
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionsThis cross-sectional study shows that mesh revision surgery alleviates symptoms in 75% of women with mesh-related complications. Type of revision surgery and individual characteristics did not seem to matter to the individual chance of cure or complications. These data can facilitate the counseling of women considering mesh revision surgery.
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
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