Letrozole and human menopausal gonadotropin for ovulation induction in clomiphene resistance polycystic ovary syndrome patients: A randomized controlled study
Objective: To compare the effects of letrozole and human menopausal gonadotropin (HMG) in the treatment of patients with polycystic ovary syndrome (PCOS) resistant to clomiphene citrate (CC). Methods: A total of 96 clomiphene resistance polycystic ovary syndrome patients infertility were randomly divided into an LE group, and HMG group (nâ=â48). LE group orally received letrozole at 5.0âmg/d−1 on the 3rd–5th days of menstrual cycle for 5 consecutive days, and 75âU/d−1 HMG was given through intramuscular injection for 5 days starting from the third day of menstrual cycle in HMG group. Number of growing and mature follicles, serum E2â(pg/mL), serum P (ng/mL), endometrial thickness, occurrence of pregnancy and miscarriage were observed. Results: There was no significant difference in the number of ovulation cycles between the 2 groups (53.6% vs 64.7%, Pâ>â.05). The number of mature follicular cycles in the HMG group was higher than that of the letrozole group (Pââ.05) and abortion rate (6.2% vs 10.4%, Pâ>â.05). There was no significant difference in the endometrial thickness between the 2 groups on the day of HCG injection [(9.1â±â0.2)âmm vs (10.7â±â1.6)âmm, Pâ>â.05]; the serum estradiol (E2) was lower in the letrozole group. The incidence of ovarian cysts was lower than that of HMG group (Pâ
Publication date: Available online 5 April 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Ayala Zilberman, Vered Eisenberg, Rakefet Yoeli, David Soriano, Eyal Sivan, Gil Golan, Roy Mashiach
Publication date: Available online 4 April 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Dr. Akshita Panwar, Dr. Kusum Lata, Dr. Amenda Ann Davis, Dr. Alka Kriplani
Publication date: Available online 4 April 2020Source: Case Reports in Women's HealthAuthor(s): Peter Khamvongsa, Naiya Patel, Ayesha Aziz Ali, Nikita Bodoukhin, Octavio Carreno
As much of the world settles into a new routine of social distancing, couples are likely to have a lot more free time to snuggle at home together. But there could be a number of risks in trying to get pregnant right now.
In this study, we aimed to assess the possible association between affective temperaments and GH.Methods: This cross-sectional study was conducted on women with GH hospitalized in hospitals affiliated with Mashhad University of Medical Sciences, compared with healthy women admitted for normal delivery in the same centers during the study. Data were collected via Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto-questionnaire (TEMPS-A) and Depression Anxiety Stress Scale (DASS) 21.Results: TEMPS-A revealed that scores anxious (P
Conclusion: This study provides evidence for blood pressure management in Chinese pregnant women. PMID: 32243195 [PubMed - as supplied by publisher]
Contributor : Daniel VaimanSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe STOX1 transcription factor has been involved in a complex human disease of pregnancy, preeclampsia, in human families, and mouse models. However, its mode of action is still largely unknown. Overexpression of either the long (STOX1A) or the short (STOX1B) isoform was obtained in the BeWo villous trophoblast model, a cell line able to fuse in syncytiotrophoblast following induction by forskolin treatment. The effects at the transcriptional level are evaluated in every condition.
Conclusion(s) Letrozole-low dose gonadotropins combination appears to be effective across different causes of infertility for superovulation. The letrozole-low dose gonadotropin combination resulted in high rate of monofolliculogenesis, low occurrence of multiple gestations and no case of OHSS or cycle cancellation.
Andrea Syrtash was first hospitalized at the age of 14 for painful and heavy menstrual cycles due to endometriosis. She had no idea her condition would affect her fertility â and even if she had known, she may not have thought to address it without guidance from her doctors. After six years of trying to conceive, Syrtash, who’s now in her 40s and works as a relationship and dating expert, recently founded pregnantish, a website for singles, couples and LGBTQ people who are trying to conceive. “When you’re a teenager, it’s not on your mind,” she said. Had she known, “I migh...
By Katrina Mark, MD 1. Fertility naturally declines as we age That alone doesn’t mean you should start to worry. The general advice I give a woman is if she has been trying to become pregnant for a full year with no luck, she might consider a fertility evaluation. For a woman over age 35, she might consider it after six months. If a woman is younger and has irregular periods, it’s likely she isn’t regularly ovulating, so she might want to be evaluated sooner. 2. Sometimes there’s a reason for infertility – and sometimes, there’s not There are some things we know cause infertility. About...