Genetically Engineered Escherichia coli Nissle 1917 Secreting GLP-1 Analog Exhibits Potential Antiobesity Effect in High-Fat Diet-Induced Obesity Mice.
CONCLUSIONS: This work has revealed that a modified live bacterial therapeutic, EcN-GM, has potential beneficial effects on obesity. This effect may be related to the regulating of the neuropeptide expression of energy intake and expenditure in the hypothalamus. This study demonstrates a successful example of engineered EcN-GM as a novel approach for weight management.
PMID: 31970910 [PubMed - in process]
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Ma J, Li C, Wang J, Gu J Tags: Obesity (Silver Spring) Source Type: research
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