Robust Optimization for Intensity-Modulated Proton Therapy to Redistribute High Linear Energy Transfer (LET) from Nearby Critical Organs to Tumors in Head and Neck Cancer

We propose linear-energy-transfer (LET)-guided robust optimization in intensity-modulated proton therapy (IMPT) for head-and-neck (H&N) cancer. This method simultaneously considers LET and physical dose distributions of tumors and organs-at-risk (OARs) with uncertainties.

Source: International Journal of Radiation Oncology * Biology * Physics - January 23, 2020 Category: Radiology Authors: Chenbin Liu, Samir H. Patel, Jie Shan, Steven E. Schild, Carlos Vargas, William W. Wong, Xiaoning Ding, Martin Bues, Wei Liu Source Type: research