Dose to Highly Functional Ventilation Zones Improves Prediction of Radiation Pneumonitis for Proton and Photon Lung Cancer Radiotherapy

We studied the relationship between radiation pneumonitis outcome from photon and proton radiotherapy to lung function for patients with locally advanced non-small cell lung cancer. The lung ventilation obtained from 4DCT was mapped with the radiation dose. We found that the dosimetric indexes to the high ventilation zones of the lung has better indication to the radiation pneumonitis compared with that to the low ventilation zones and the traditional whole lung dosimetric indexes.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research

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ConclusionNivolumab appeared to be safe and effective in Taiwanese patients. These interim results suggest that nivolumab is a suitable treatment option for this population.Clinical trial registrationNCT02582125.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
CONCLUSIONS: We strictly determined prognostic genes of NSCLC, which would contribute to its carcinogenesis investigation and therapeutic methods improvement. PMID: 32083573 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
CONCLUSIONS: These results indicated that OCEL1 protein may serve as a novel prognostic biomarker in NSCLC. PMID: 32083572 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
ConclusionsThe population PK of PF-06439535 and bevacizumab-EU were well characterized by a two-compartment model. Covariate analysis did not reveal any appreciable differences between PK parameters for PF-06439535 and bevacizumab-EU in patients with NSCLC.Clinical trial, NCT02364999.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 20 February 2020Source: Acta Pharmaceutica Sinica BAuthor(s): Kudelaidi Kuerban, Xiwen Gao, Hui Zhang, Jiayang Liu, Mengxue Dong, Lina Wu, Ruihong Ye, Meiqing Feng, Li YeAbstractMore efficient drug delivery system and formulation with less adverse effects are needed for the clinical application of broad-spectrum antineoplastic agent doxorubicin (DOX). Here we obtained outer-membrane vesicles (OMVs), a nano-sized proteoliposomes naturally released by Gram-negative bacteria, from attenuated Klebsiella pneumonia and prepared doxorubicin-loaded OMVs (DOX-OMV). Confocal microscopy and in vivo ...
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
Lung adenocarcinoma (LUAD) is a common histological type of non-small cell lung cancer (NSCLC), accounting for nearly 40% of all lung cancers [1]. Current research has identified several LUAD-specific oncoproteins with differential expression of wildtype or mutant forms, which includes the REarranged during Transfection (RET) receptor tyrosine kinase (RTK). The expression and activation of RET has been implicated in multiple cancers, including lung [2,3]. RET is expressed at low levels in normal lung tissues, however RET gene rearrangements give rise to chimeric proteins with constitutive kinase activity that drive tumouri...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
ConclusionIn conclusion, ALO –Adbic combination can produce synergistic anti-cancer effects at low doses, and may offer a more effective and less toxic new treatment strategy for NSCLC.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
AbstractObjectiveLung adenosquamous carcinoma (ASC) is a rare histological subtype of non-small cell lung cancer (NSCLC). Due to its rarity, the studies about18F-FDG PET/CT in this kind of pulmonary tumor were quite limited. Thus, this study investigated18F-FDG PET/CT findings in ASC and its correlation with clinicopathological features and clinical outcomes.MethodsPreoperative18F-FDG PET/CT findings and parameters of maximum standard uptake value (SUVmax), metabolic tumor volume and total lesion glycolysis of primary lesion (MTV-P, TLG-P), combination of primary lesion and metastases (MTV-C, TLG-C), and clinicopathologica...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
In conclusion, curcumin inhibited cell invasion and migration in NSCLC by elevating the expression of miR-206 which further suppressed the activation of the PI3K/AKT/mTOR pathway. PMID: 32074070 [PubMed - in process]
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Publication date: Available online 20 February 2020Source: Journal of Integrative MedicineAuthor(s): Varuni Colamba Pathiranage, Ira Thabrew, Sameera R. Samarakoon, Kamani H. Tennekoon, Umapriyatharshini Rajagopalan, Meran K. EdiriweeraAbstractObjectiveThe present work tested organic solvents to prepare an extract with anticancer properties from a polyherbal mixture containing Nigella sativa (seeds), Hemidesmus indicus (roots) and Smilax glabra (rhizomes). We evaluate anticancer effects in non-small-cell lung cancer cells (NCI-H292), and discuss optimization for pharmaceutical use in the context of efficacy, yield and toxi...
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
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