Roche provides an update on Phase III study of Tecentriq in people with muscle-invasive urothelial cancer

            Basel, 24 January 2020 – Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the Phase III IMvigor010 study evaluating Tecentriq® (atezolizumab) as an adjuvant (after surgery) monotherapy treatment did not meet its primary endpoint of disease-free survival (DFS) compared to observation in people with muscle-invasiv e urothelial cancer (MIUC). Safety for Tecentriq appeared consistent with the known safety profile of the medicine, and no new safety signals were identified.“Reducing the risk that muscle-invasive urothelial cancer will recur after surgery is very difficult, and we are disappointed that we were not able to significantly prolong disease-free survival,” said Levi Garraway, M.D., Ph.D., Chief Medical Officer and Head of Global Product Development. “W e remain committed to exploring the potential benefits of immunotherapy for more people with early cancers.” The goal in treating MIUC early is to reduce the risk of the disease recurring or spreading to other parts of the body. More treatment options following surgery are needed as approximately half of people with MIUC will develop a recurrence of their disease within 2 years of surgery.1 In addition to ongoing Phase III studies in early and advanced bladder cancer, Roche has an extensive development programme for Tecentriq, including multiple ongoing and planned Phase III studies across several types of lung, genitourinary, skin, brea...
Source: Roche Investor Update - Category: Pharmaceuticals Source Type: news

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Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
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Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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Source: Journal of Adolescence - Category: Child Development Source Type: research
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Source: Food Quality and Preference - Category: Food Science Source Type: research
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Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research
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Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
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Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
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