Microscopic precursor lesions of uterine lymphangioleiomyomatosis associated with incidental nodal lymphangioleiomyomatosis: A case report and discussion of pathogenesis

Publication date: March 2020Source: Human Pathology: Case Reports, Volume 19Author(s): Charles M. LombardAbstractA 47 yo woman underwent resection of an endometrial adenocarcinoma with pelvic lymph node biopsies. She was found to have incidental nodal lymphangioleiomyomatosis (LAM). Subsequent clinical and radiographic evaluation showed no evidence of manifestations of tuberous sclerosis or pulmonary LAM. Examination of the uterus revealed small microscopic foci of myometrial precursor LAM lesions. These lesions were detected only by immunohistochemical stains for cathepsin K and HMB-45. It is proposed that the precursor cell for the LAM cell is an altered Müllerian smooth muscle cell.
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research