Rheumatoid factor-producing CD21low anergic clonal B-cells in essential mixed cryoglobulinaemia: a model for autoantigen-driven pathogenesis of infectious and non-infectious cryoglobulinaemias.

CONCLUSIONS: Our findings suggest a common pathogenetic mechanism in EMC, HCV-MC and primary Sjögren's syndrome, consisting of autoantigen-driven clonal expansion and exhaustion of selected RF-producing B-cells. The more massive clonal expansion in HCV-MC may be due to co-stimulatory signals provided by the virus. PMID: 31969220 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31969220?dopt=Abstract

Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research