P155 therapeutic effect of ops-2071 on healing of t cell-mediated colitis, a murine model of crohn ’s disease, with anti-inflammatory and antibacterial activity

Crohn ’s disease (CD) is a form of chronic inflammatory bowel disease (IBD). Although CD is an immune-mediated condition of unknown etiology, many studies suggested that abnormal immune responses against certain intestinal bacteria may trigger development of chronic inflammation. The T cell-mediated col itis model is a well characterized adaptive transfer murine model of chronic small bowel and colonic inflammation that resembles human CD (e.g., diarrhea, a heavily inflamed colon, loss of mucus from goblet cells, Th1/Th17 dominated cytokine profile).

Source: Gastroenterology - January 25, 2020 Category: Gastroenterology Authors: Hiroko Takagi, Masayoshi Sato, Kazuyuki Fujii, Isao Shibuya, Daisuke Oka, Naomitsu Yamaya, Katsuya Inagaki Tags: Animal Models: Pre-Clinical Treatment of Intestinal Inflammation Source Type: research