16 ccl11 exacerbates colitis via modulation of epithelial wound repair

We have shown that CCL11 (eotaxin-1), an eosinophil chemoattractant, is significantly increased in the serum of ulcerative colitis and Crohn ’s disease patients vs controls and is also increased in dextran sulfate sodium (DSS)-induced murine colitis. In response to azoxymethane (AOM)-DSS, Ccl11–/– mice have significantly decreased colonic tumor number and burden, histologic injury, and colonic eosinophil infiltration vs wild-type ( WT) mice. Ccl11 is expressed by isolated colonic epithelial and lamina propria immune cells.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Cytokines, Signaling and Receptors Source Type: research