P150 enhancing epithelial barrier function with novel e-cadherin activating monoclonal antibodies reduces inflammatory bowel disease progression in mouse models

Deficits in gastrointestinal (GI) epithelial barrier function play important roles in the pathogenesis of Inflammatory Bowel Disease (IBD). The CDH1 gene encoding E-cadherin, a key component of the epithelial junctional complex, is associated with Ulcerative Colitis (UC), and perhaps Crohn ’s disease (CD). E-cadherin is the principle adhesive component of the adherens junction, and it regulates paracellular permeability by facilitating the formation of tight junctions and organizing the entire epithelial junction complex.

Source: Gastroenterology - January 25, 2020 Category: Gastroenterology Authors: Chirosree Bandyopadhyay, Leslayann Schecterson, Barry Gumbiner Tags: Epithelial Cell Biology/Function in Inflammation Source Type: research