P143 epithelial-derived selenoprotein p protects from colitis-associated carcinogenesis
Patients with inflammatory bowel disease demonstrate selenium nutritional deficiencies and are at increased risk for colon cancer. Previously, we determined that global loss of the selenium-containing antioxidant protein, Selenoprotein P (SELENOP), exacerbates experimental colitis-associated cancer (CAC). Using a variety of tissue-specific knockout mouse lines, we further determined that epithelial-derived SELENOP served as the primary mediator of disease severity, and Villin-Cre; Selenop f/f (Selenop ΔIEC) mice have increased tumor incidence, number, size, and dysplasia as compared to WT cohorts.
Source: Gastroenterology - Category: Gastroenterology Authors: Sarah Short, Vishruth Reddy, Jared Hendren, Yael Haberman, Jennifer Pilat, Benjamin Marsh, Mary Washington, Jeffrey Hyams, Ted Denson, Michael Rosen, Christopher Williams Tags: Epithelial Cell Biology/Function in Inflammation Source Type: research
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