9 metabolic utilization of propanediol by adherent-invasive e.  coli regulates intestinal tissue immunity

While the molecular mechanisms by which the microbiome modulates mucosal immunity in Crohn ’s disease (CD) are still largely unknown, recent data highlight the involvement of specific diet- and bacterial-derived metabolites in the regulation of intestinal immune cell activation and differentiation. We have recently shown that Adherent-Invasive E.coli (AIEC), which are enriched in CD pat ients, are sufficient to induce intestinal Th17 cells. Although AIEC lack pathogenic factors including type III secretion systems, many CD-derived isolates express virulence-associated metabolic enzymes including propanediol dehydratase (PduC), which enables AIEC to use fucose-derived propanediol as an alternate carbon source in the gut.

Source: Gastroenterology - January 25, 2020 Category: Gastroenterology Authors: Monica Viladomiu, Maeva Metz, Svetlana Lima, Chun-Jun Guo, Kenneth Simpson, Randy Longman Tags: Innate and Mucosal Immunology and Immunity Source Type: research