P164 epithelial tlr4-induced dysbiosis increases susceptibility to tumorigenesis

Toll-like receptor 4 (TLR4), the receptor for gram negative lipopolysaccharide, is upregulated in biopsies of ulcerative colitis and colorectal cancer (CRC) patients, particularly in intestinal epithelial cells (IECs). We have demonstrated that activation of TLR4 promotes redox activity in IECs and induces susceptibility to colitis, colitis-associated cancer (CAC) and CRC. Furthermore, we have shown that TLR4-induced susceptibility to colitis is transmissible by simple cohousing, suggesting that the microbiota plays a key role in TLR4-driven effects.

Source: Gastroenterology - January 25, 2020 Category: Gastroenterology Authors: Juan Burgueno, Julia Fritsch, Ana Santander, Nivis Brito, Irina Fernandez, Judith Pignac-Kobinger, Gregory Conner, Maria Abreu Tags: Microbiome Source Type: research