P005 a survey study of gastroenterologists' views on dysplasia surveillance and chromoendoscopy in ibd

The objective of this study is to assess gastroenterologists ’ current attitudes and barriers toward chromoendoscopy in IBD.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Practice Management/Quality of Care/Quality Assurance Source Type: research

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Publication date: Available online 8 February 2020Source: Microbial PathogenesisAuthor(s): Rasoul Mirzaei, Hamed Mirzaei, Mohammad Yousef Alikhani, Mohammad Sholeh, Mohammad Reza Arabestani, Masoud Saeedijam, Sajad Karampoor, Yaghoub Ahmadyousefi, Mohammad Shokri Moghadam, Gholam Reza Irajian, Hamze Hasanvand, Rasoul YousefimashoufAbstractHuman colorectal cancer is the third most common cancer around the world. Colorectal cancer has various risk factors, but current works have bolded a significant activity for the microbiota of the human colon in the development of this disease. Bacterial biofilm has been mediated to non-m...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionThis explanatory RCT evaluated the efficacy of colonoscopy screening by valid statistical inference based on randomization. Data on adverse events from this kind of screening are necessary when considering implementation of future screening programs.Trial registrationUMIN Clinical Trials Registry, number UMIN000001980.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Abstract S100B protein bridges chronic mucosal inflammation and colorectal cancer given its ability to activate NF-kappaB transcription via RAGE signalling and sequestrate pro-apoptotic wtp53. Being an S100B inhibitor, pentamidine antagonizes S100B-wtp53 interaction, restoring wtp53-mediated pro-apoptotic control in cancer cells in several types of tumours. The expression of S100B, pro-inflammatory molecules and wtp53 protein was evaluated in human biopsies deriving from controls, ulcerative colitis and colon cancer patients at baseline (a) and (b) following S100B targeting with niosomal PENtamidine VEhiculation (...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
Abstract Both human epidemiologic data and animal studies suggest that low serum vitamin D increases the risk of inflammatory bowel disease (IBD) and consequently IBD-associated colorectal cancer. We tested the hypothesis that vitamin D deficiency increases the risk for colitis-associated colon cancer (CAC) by using an established CAC mouse model, 129-Smad3tm1Par/J(Smad3-/-) mice, which have defective transforming growth factor β-signaling and develop colitis and CAC after the administration of dextran sodium sulfate (DSS). After determining a dietary regimen that induced chronic vitamin D deficiency in Smad3...
Source: Comparative Medicine - Category: Zoology Authors: Tags: Comp Med Source Type: research
Abstract Nano-drug delivery systems (NDDS) for colon-targeted drug delivery are an active area of research on local diseases affecting the colon, such as ulcerative colitis, Crohn's disease, colon cancer, and for the delivery of peptide or protein drugs and vaccinations. In particular, targeted nano-drug delivery to the colon is advantageous for colon-specific diseases because nanoparticles can accumulate in diseased parts, improve the efficacies of therapeutics, and enable localized treatments, which reduces systemic toxicity. However, there are many hurdles, such as burst drug release, enzyme and acidic degradat...
Source: Archives of Pharmacal Research - Category: Drugs & Pharmacology Authors: Tags: Arch Pharm Res Source Type: research
Patients with inflammatory bowel disease demonstrate selenium nutritional deficiencies and are at increased risk  for colon cancer. Previously, we determined that global loss of the selenium-containing antioxidant protein, Selenoprotein P (SELENOP), exacerbates experimental colitis-associated cancer (CAC). Using a variety of tissue-specific knockout mouse lines, we further determined that epithelial-derived SELENOP served as the primary mediator of disease severity, and Villin-Cre; Selenop f/f (Selenop ΔIEC) mice have increased tumor incidence, number, size, and dysplasia as compared to WT cohorts.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Epithelial Cell Biology/Function in Inflammation Source Type: research
ConclusionsThese observations suggest that SYD is effective in the enhancement of antioxidant ability via activation of Nrf2 pathway and the up-regulation of Nrf2-downstream phase II enzymes expression. The anti-inflammation and antioxidant action of SYD together contributes to the prevention and treatment of ulcerrelated colorectal cancer.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, the bft gene was found to be associated with CRC, especially in the patients with precancerous lesions and initial carcinogenic lesions. Moreover, the results suggest that mucosal BFT exposure is common and could be a risk factor and a screening marker for developing CRC.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Publication date: 11–17 January 2020Source: The Lancet, Volume 395, Issue 10218Author(s): Oriana M Damas, Maria T Abreu
Source: The Lancet - Category: General Medicine Source Type: research
This study aimed to utilize a validated bowel function survey to determine which symptoms are present after J-pouch creation, and whether patients display a functional profile similar to low anterior resection syndrome. DESIGN: This study is a retrospective analysis of a prospectively maintained single-center database. SETTINGS: This study was conducted at the colorectal surgery center of a tertiary care academic hospital PATIENTS: Included were 159 patients with J-pouch, ≥6 months after ileostomy reversal. MAIN OUTCOME MEASURES: The primary outcomes were individual answers to the Memorial Sloan Kettering Ca...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contributions: Inflammatory Bowel Disease Source Type: research
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