Overexpression of molecule GRP94 favors tumor progression in lung adenocarcinoma by interaction with regulatory T cells
ConclusionsOur study revealed that that GRP94 expression in lung AD favors tumor progression and predicts poor prognosis. The oncogenic role of GRP94 may involve inducing Treg infiltration by promoting the TGF ‐β signaling pathway.Key points
GRP94 protein levels were elevated in lung AD tissues compared to normal lung tissues. The high expression ofGRP94 in lung AD favors tumor progression and predicts poor prognosis.
The oncogenic role of the molecule GRP94 may involve the stimulation of Treg infiltrationvia promotion of the TGF ‐β signaling pathway.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Xiao ‐Feng Duan,
Ya‐Wei Xin Tags: ORIGINAL ARTICLE Source Type: research
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