Ras mediated activation of NF- κB and DNA damage response in carcinogenesis.

Ras mediated activation of NF-κB and DNA damage response in carcinogenesis. Cancer Invest. 2020 Jan 23;:1-58 Authors: Ahmad A, Ahsan H Abstract Cancer is a multi-step process during which cells acquire mutations that eventually lead to uncontrolled cell growth and division and evasion of programmed cell death. The oncogenes such as Ras and c-Myc may be responsible in all three major stages of cancer i.e. early, intermediate and late. The NF-κB has been shown to control the expression of genes linked with tumor pathways such as chronic inflammation, tumor cell survival, anti-apoptosis, proliferation, invasion and angiogenesis. In the last few decades, various biomarker pathways have been identified that play a critical role in carcinogenesis such as Ras, NF-κB and DNA damage. PMID: 31971023 [PubMed - as supplied by publisher]
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research