Osteoporosis Entwined with Cardiovascular Disease: The Implication of Osteoprotegerin and Example of Statins.

Osteoporosis Entwined with Cardiovascular Disease: The Implication of Osteoprotegerin and Example of Statins. Curr Med Chem. 2020 Jan 23;: Authors: Deligiorgi MV, Panayiotidis MI, Siasos G, Trafalis DT Abstract Beyond being epiphenomenon of shared epidemiological factors, the integration of osteoporosis (OP) with cardiovascular disease (CVD)- termed "calcification paradox"- reflects a continuum of aberrant cardiometabolic status. The present review provides background knowledge on "calcification paradox", focusing on the endocrine aspect of vasculature orchestrated by the osteoblastic molecular fingerprint of vascular cells, acquired via imbalance among established modulators of mineralization. Osteoprotegerin (OPG)-the well-established osteoprotective cytokine-has recently been shown to exert a vessel-modifying role. Prompted by this notion, the present review interrogates OPG as the potential missing link between OP and CVD. However, so far, the confirmation of this hypothesis is hindered by the equivocal role of OPG in CVD, being both proatherosclerotic and antiatherosclerotic. Further research is needed to illuminate whether OPG could be biomarker of the "calcification paradox". Moreover, the present review brings into prominence the dual role of statins-cardioprotective and osteoprotective- as potential illustration of the integration of CVD with OP. Considering that the statins-induced modulation of OPG is central to the statin...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research