Comparison of mediastinal shift angles obtained with ultrasound and magnetic resonance imaging in fetuses with isolated left sided congenital diaphragmatic hernia

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Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research

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Minimally invasive repair of esophageal atresia with tracheoesophageal fistula (EA/TEF) and congenital diaphragmatic hernia (CDH) is feasible and confers benefits compared to thoracotomy or laparotomy. However, carbon dioxide (CO2) insufflation can lead to hypercapnia and acidosis. We sought to determine the effect of lower insufflation pressures on patients' surrogate markers for CO2 absorption — arterial partial pressure of CO2 (PaCO2), end tidal CO2 (EtCO2) and pH.
Source: Journal of Pediatric Surgery - Category: Surgery Authors: Source Type: research
Journal of Perinatology, Published online: 21 February 2020; doi:10.1038/s41372-020-0612-6Survival of infants with congenital diaphragmatic hernia in California: impact of hospital, clinical, and sociodemographic factors
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
Journal of Perinatology, Published online: 20 February 2020; doi:10.1038/s41372-020-0623-3An omic approach to congenital diaphragmatic hernia: a pilot study of genomic, microRNA, and metabolomic profiling
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
(Johns Hopkins Medicine) Researchers from The Johns Hopkins Center for Fetal Therapy report new evidence that fetuses with severe congenital diaphragmatic hernia (CDH), a rare but life-threatening, lung-damaging condition, experience a significantly high rate of success for the fetal treatment known as FETO, if they and their mothers receive coordinated and highly experienced care in the same expert setting.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
rra-Rios D, Ordorica-Flores R, Nieto-Zermeño J Abstract OBJECTIVE: To evaluate the impact of Fetal Endoscopic Tracheal Occlusion (FETO) in improving survival for fetuses with severe left congenital diaphragmatic hernia (CDH) and temporary cases managed expectantly during pregnancy in a country with suboptimal neonatal management. METHODS: A cohort of consecutive, isolated left-sided CDH fetuses with normal karyotype and severe pulmonary hypoplasia (liver herniation and observed/expected lung area to head ratio below 26%) were selected for FETO at less than 32 weeks of gestation in a single terti...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
Abstract OBJECTIVES: Congenital diaphragmatic hernia (CDH) can cause significant mass effect in the fetal thorax displacing the heart into the opposite hemithorax. In left CDH (L-CDH), this is associated with smaller left-sided cardiac structures and lower left ventricular cardiac output (LVCO). The effect of these physiologic changes on cerebral blood flow is not well understood. We sought to describe the middle cerebral artery pulsatility index (MCA PI), a measure of vascular impedance, in L-CDH and right CDH (R-CDH) versus unaffected fetuses, and the relationship of MCA PI to LVCO. We hypothesized that MCA PI i...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
We sought to identify implementation barriers and opportunities to increase utilization of the Canadian Congenital Diaphragmatic Hernia (CDH) Collaborative's clinical practice guideline.
Source: Journal of Pediatric Surgery - Category: Surgery Authors: Source Type: research
AbstractCongenital diaphragmatic hernia (CDH) is a developmental birth defect consisting of a diaphragmatic defect and abnormal lung development. CDH complicates 2.3 –2.8 per 10,000 live births. Despite efforts to standardize clinical practice, management of CDH remains challenging. Frequent re-evaluation of clinical practices in CDH reveals that management of CDH is evolving from one of postnatal stabilization to prenatal optimization. Translational research reveals promising avenues for in utero therapeutic intervention, including fetoscopic endoluminal tracheal occlusion. These remain highly experimental and deman...
Source: Pediatric Surgery International - Category: Surgery Source Type: research
Journal of Perinatology, Published online: 17 February 2020; doi:10.1038/s41372-020-0615-3Left-sided congenital diaphragmatic hernia: can we improve survival while decreasing ECMO?
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
Abstract The aim of this study was to investigate the therapeutic effects and underlying mechanism of tetramethylpyrazine (TMP) on lung development using a rat model of congenital diaphragmatic hernia (CDH). Nitrofen was used to induce CDH. Pregnant rats were divided into three groups: control, CDH, and CDH+TMP. In the CDH and CDH+TMP, fetuses only with left diaphragmatic hernias were chosen for analysis. Lung and body weight were recorded and lung histologic evaluations, image analysis, and western blot analysis of YAP, p-YAP and LATS1 were performed after lung processing. A markedly abnormal structure was observ...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
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