Copper-mediated oxidative [3+2]-annulation of nitroalkenes and pyridinium imines: efficient synthesis of 3-fluoro- and 3 nitro-pyrazolo[1,5-a]pyridines

Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9OB02668A, PaperVladimir Motornov, Andrey Tabolin, Yulia V. Nelyubina, Valentine Nenajdenko, Sema Ioffe An efficient route to pyrazolo[1,5-a]pyridines by Cu(OAc)2 ∙H2O-promoted oxidative [3+2]-annulation of nitroalkenes with in situ generated pyridinium imines was developed. The reaction with α-fluoronitroalkenes provides the first preparative synthesis of 3-fluoro-pyrazolo[1,5-a]pyridines.... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - January 24, 2020 Category: Molecular Biology Authors: Vladimir Motornov Source Type: research