TP53 gene variant in people of African descent linked to iron overload, may improve malaria response

(The Wistar Institute) In a study by Wistar and collaborators, a rare, African-specific variant of the TP53 gene called P47S causes iron accumulation in macrophages and other cell types and is associated with poorer response to bacterial infections, along with markers of iron overload in African Americans. Macrophage iron accumulation disrupts their function, resulting in more severe bacterial infections.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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A group of moderately ill people were given hydroxychloroquine, which appeared to ease their symptoms quickly, but more research is needed.
Source: NYT - Category: American Health Authors: Tags: Coronavirus (2019-nCoV) Hydroxychloroquine (Drug) Drugs (Pharmaceuticals) Quarantines Shortages Autoimmune Diseases Pneumonia Immune System Malaria Schaffner, William your-feed-healthcare Source Type: news
Matthew FeeneyDeadly misinformation spread across social media long before COVID-19 emerged, but amid the ongoing pandemic attempts to tackle such content are once again in the limelight. These efforts provide an opportunity for classical liberals to emphasize the importance of freedom of association and to prepare for discussions about how private institutions handle misinformation amid a  crisis.Too often we think of the freedom of speech to be a  freedom that protects speakers from government censorship. And while the freedom to speak is a necessary condition for a functioning liberal society it&rsqu...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
[Daily Maverick] While the promise of repositioning 'old' drugs such as chloroquine and hydroxychloroquine is tantalising, it is critical that the hazards of using unapproved treatments are shared with the public to prevent needless fatalities and supply shortages that may further burden already strained healthcare systems.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
Drug maker Amneal is donating 400,000 doses of hydroxychloroquine to Louisiana in the hopes of helping the state fight coronavirus, which has struck more than 4,000 people there, killing 185.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
[Premium Times] 12 former African leaders, including former Nigerian president, Olusegun Obasanjo, have called for an emergency plan to combat the COVID-19 onslaught in Africa at a continental or regional level.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
TUESDAY, March 31, 2020 -- With little evidence that the malaria drugs hydroxychloroquine and chloroquine can prevent or treat COVID-19, the U.S. Food and Drug Administration has given emergency approval to distribute millions of doses of the...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Condition:   Malaria (Plasmodium Falciparum) Interventions:   Drug: Meplazumab for Injection;   Drug: Sterile normal saline (0.9%) Sponsor:   Jiangsu Pacific Meinuoke Bio Pharmaceutical Co Ltd Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Malaria, Malaria Vaccine, Insecticide-treated Bednets Interventions:   Biological: RTS,S/AS01 malaria vaccine;   Other: PBO bed nets Sponsors:   Michigan State University;   University of Malawi College of Medicine;   University of Maryland, College Park;   Boston University;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Malaria (Plasmodium Falciparum) Interventions:   Drug: Meplazumab for Injection;   Drug: Sterile normal saline (0.9%) Sponsor:   Jiangsu Pacific Meinuoke Bio Pharmaceutical Co Ltd Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Malaria, Malaria Vaccine, Insecticide-treated Bednets Interventions:   Biological: RTS,S/AS01 malaria vaccine;   Other: PBO bed nets Sponsors:   Michigan State University;   University of Malawi College of Medicine;   University of Maryland, College Park;   Boston University;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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