a Nationwide Case-Cohort Study.

We examined whether the use of antiasthmatic drugs was associated with the development of type 1 diabetes in childhood in a nationwide, register-based case-cohort study. We identified all children who were born 1.1.1995-31.12.2008 in Finland and diagnosed with type 1 diabetes by 2010 (n = 3,342). A 10% random sample from each birth year cohort was selected as a reference cohort (n = 80,909). Information on all dispensed antiasthmatic drugs (the Anatomical Therapeutic Chemical classification system code R03) during 1995-2009 were obtained, and the associations between the use of antiasthmatic drugs and the development of type 1 diabetes were investigated using time-dependent and time-sequential Cox regression models. Dispensed inhaled corticosteroids and inhaled β-agonists were associated with an increased risk of type 1 diabetes after adjusting for other antiasthmatic drugs, asthma, sex, and birth decade (hazard ratio = 1.29; 95% confidence interval: 1.09, 1.52, and hazard ratio = 1.22; 95% confidence interval: 1.07, 1.41, respectively. These findings suggest that children using inhaled corticosteroids or inhaled β-agonists may be at increased risk of type 1 diabetes. PMID: 31971234 [PubMed - as supplied by publisher]
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research