a Nationwide Case-Cohort Study.

We examined whether the use of antiasthmatic drugs was associated with the development of type 1 diabetes in childhood in a nationwide, register-based case-cohort study. We identified all children who were born 1.1.1995-31.12.2008 in Finland and diagnosed with type 1 diabetes by 2010 (n = 3,342). A 10% random sample from each birth year cohort was selected as a reference cohort (n = 80,909). Information on all dispensed antiasthmatic drugs (the Anatomical Therapeutic Chemical classification system code R03) during 1995-2009 were obtained, and the associations between the use of antiasthmatic drugs and the development of type 1 diabetes were investigated using time-dependent and time-sequential Cox regression models. Dispensed inhaled corticosteroids and inhaled β-agonists were associated with an increased risk of type 1 diabetes after adjusting for other antiasthmatic drugs, asthma, sex, and birth decade (hazard ratio = 1.29; 95% confidence interval: 1.09, 1.52, and hazard ratio = 1.22; 95% confidence interval: 1.07, 1.41, respectively. These findings suggest that children using inhaled corticosteroids or inhaled β-agonists may be at increased risk of type 1 diabetes. PMID: 31971234 [PubMed - as supplied by publisher]
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research

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In those who already have asthma, the risk for type 1 diabetes is increased, but not the other way around.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Diabetes & Endocrinology News Source Type: news
FRIDAY, March 13, 2020 -- There is evidence for co-occurrence and coaggregation of asthma and type 1 diabetes in children and their siblings, according to a study published online March 13 in JAMA Network Open. Awad I. Smew, M.D., from the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Abstract The aim of this narrative review is to summarize the present knowledge on long-term outcome of children born after assisted reproductive technologies (ART). The main outcomes covered are neurodevelopment including cerebral palsy, cognitive development, attention deficit hyperactivity disorder and autism spectrum disease, growth, cardiovascular function, diabetes type 1, asthma, malignancies, and reproductive health. Results have mainly been obtained from systematic reviews/meta-analyses and large registry studies. It has been shown that children born after ART, when restricted to singletons, have a simila...
Source: Upsala Journal of Medical Sciences - Category: General Medicine Authors: Tags: Ups J Med Sci Source Type: research
Conclusion IEC 62366-1 leaves a chasm between Normal Use and Abnormal Use, so manufacturers might not consider some user actions to be “Use Errors” if these actions do not fit the IEC 62366-1 definition of use. In other words, Use Errors may go undetected, unaddressed, or unmitigated. To protect users and manufacturers, this gap must be closed: IEC 62366-1 should be updated to address user actions that do not fit the current definitions of Normal Use nor Abnormal Use. To mend this gap in IEC 62366-1, we suggest to: Re-define Abnormal Use in terms of abuse. Remove Normal Use. Remove the &...
Source: MDDI - Category: Medical Devices Authors: Tags: Design Source Type: news
Originally, a Trojan horse referred to the wooden horse used to cunningly penetrate and conquer the city of Troy by the Greeks. In our era, the term has been adapted to describe disguised malwares that attack unsuspecting users’ computers and wreak havoc once inside. Judging by the title of this article, how then can a condition as serious as diabetes help move the digital health agenda forward? Computer generated 3D illustration with the Trojan Horse at Troy, source: http://codingtidbit.com/ Once upon a time, empowered patients started a revolution…  It all begins with a crippling speed of bure...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: E-Patients Future of Medicine Healthcare Design diabetes digital health diabetes management patient design Source Type: blogs
CONCLUSION: JIA appears to be associated with an increased risk of T1D compared to asthma and healthy children. PMID: 31787600 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
CONCLUSIONS: At adolescence, both Crohn's disease and ulcerative colitis are associated with multiple comorbidities, not limited to autoimmune disorders. PMID: 31801156 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Publication date: Available online 19 November 2019Source: Journal of Functional FoodsAuthor(s): Lucía Diez-Gutiérrez, Leire San Vicente, Luis Javier R. Barrón, María del Carmen Villarán, María ChávarriAbstractProbiotics have attracted growing interest in recent decades due to their multiple health benefits. The synergistic relationship between probiotics and prebiotics can enhance the production of metabolites called postbiotics, which are gaining increasing importance because of their beneficial functions in the gastrointestinal tract and their influence on different organ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Amidst news of several Congressional hearings on the topic earlier in 2019, and continued protests by patient advocates outside of insulin manufacturers'headquarters, as well as persistent patient and caregiver complaints about runaway U.S. insulin prices in the U.S. media, a less-acknowledged change occurred which could impact what many patients with diabetes pay next year for insulin and testing supplies.It's not often that Americans would actually wish to THANK the Treasury Department and the Internal Revenue Service (IRS), but in 2020, perhaps many Americans with diabetes might wish to do that!On July 17, 2019, the IRS...
Source: Scott's Web Log - Category: Endocrinology Tags: 2019 2020 drug prices insulin insulin prices IRS Source Type: blogs
AbstractThe immune system when acts against selfmolecules results in an imbalance in immunologic tolerance leading to the development of several autoimmune diseases (ADs) such as rheumatoid arthritis, asthma, ulcerative colitis, type 1 diabetes, and multiple sclerosis. Improved recognition of the mechanisms of ADs has led to the advancement of the management of these diseases. The principal mediators of ADs are inflammatory molecules. The herbal medicines due to their antioxidant and antiinflammatory properties have an important role in the management of ADs. Crocin is the principal chemical component extracted from saffro...
Source: BioFactors - Category: Biochemistry Authors: Tags: REVIEW ARTICLE Source Type: research
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