Mechanism of action of cocoa on bone metabolism in calcium- and estrogen-deficient rat model of osteoporosis: Evidence for site and dose-related responses and involvement of IGF-I

Publication date: March 2020Source: Journal of Functional Foods, Volume 66Author(s): Bahareh Sarmadi, Amin Ismail, Loqman Yusof, Mohd Faridz Mod YunohAbstractThe present study evaluated the impact of cocoa on skeleton of ovariectomized rats. Animals were randomized into four groups: sham (basal diet: AIN-93M Ca and P-deficient), and three ovariectomized groups: OVX (basal diet), C6 and C12 (6% and 12% cocoa powder, respectively). Urinary calcium loss was decreased in C6 but not C12, while serum insulin-like growth factor (IGF)-I increased in both cocoa groups. Improvement in bone quality and strength was observed in femur mid-shaft in C6 but not C12. Bone density, quality and strength of lumbar vertebrae were improved in both cocoa groups. Cocoa improved systemic oxidative stress and inflammatory biomarkers. In bone tissue of C12, higher levels of H2O2 and lower levels of glutathione peroxidase (GPx) were observed. Cocoa down-regulated osteoblast- and osteoclast-related genes while up-regulated GPx and superoxide dismutase (SOD). Cocoa decreased bone turnover in ovariectomized rats. Its effects depended on the dose applied and the bone site.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research

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AbstractSummaryWe found that the MRI T2* value is moderately negatively correlated with the bone mineral density assessed with quantitative computed tomography in evaluating osteoporosis in postmenopausal women and may have some potential in assessing severity of lumbar osteoporosis for scientific research.PurposeTo investigate the T2* quantitative measurement in magnetic resonance imaging (MRI) and its correlation with the bone mineral density (BMD) values evaluated with quantitative computed tomography (QCT) in women with postmenopausal lumbar vertebrae osteoporosis.Materials and methodsEighty-seven postmenopausal women ...
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
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Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
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Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
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Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
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Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
ABSTRACTVitamin D (VitD) is commonly prescribed to normalise deficiencies and to treat osteoporosis. However, the effect VitD supplements have on skeletal muscle health is equivocal. While VitD is known to play a role in the various processes that maintain muscle integrity and function, recent studies utilising high bolus dose VitD supplementation has demonstrated an increased risk of falls. Thus, the aim of this study was to investigate the effects of high VitD supplementation on skeletal muscle function with and without exercise enrichment. Four ‐week old C57BL/10 mice (n = 48) were separated into either norm...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
Updated guidance for osteoporosis now includes a recommendation for the use of romosozumab, but only in severe osteoporosis and not in women with a history of myocardial infarction or stroke.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Diabetes & Endocrinology News Source Type: news
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