Practical approach to diagnosis of bland-looking spindle cell lesions of the breast.
Practical approach to diagnosis of bland-looking spindle cell lesions of the breast. Pathologica. 2019 Dec;111(4):344-360 Authors: Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM Abstract The diagnosis of bland-looking spindle cell lesions of the breast is often challenging because there is a close morphological and immunohistochemical overlap among the different entities. The present review will discuss reactive spindle cell nodule/exuberant scar, nodular fasciitis, inflammatory pseudotumor, myofibroblastoma (classic type), lipomatous myofibroblastoma, palisaded myofibroblastoma, benign fibroblastic spindle cell tumor, spindle cell lipoma, fibroma, leiomyoma, solitary fibrous tumor, myxoma, schwannoma/neurofibroma, desmoid-type fibromatosis, dermatofibrosarcoma protuberans, low-grade fibromatosis-like spindle cell carcinoma, inflammatory myofibroblastic tumor and low-grade myofibroblastic sarcoma arising in the breast parenchyma. The pathologist should be aware of each single lesion to achieve a correct diagnosis to ensure patient a correct prognostic information and therapy. Accordingly representative illustrations and morphological/immunohistochemical diagnostic clues will be provided. PMID: 31965112 [PubMed - in process]
CONCLUSIONS: In cases of BCCs with thickness of ≤1 mm, there was a high correlation (r=0.870) of the tumor spread depth between micromorphological measurements and the results obtained using a 75 MHz transducer and in cases of BCCs with thickness of>1 mm, a very high correlation (r=0.951) of the tumor spread depth was observed between histomorphometry and30 MHz transducer measurements. PMID: 32096785 [PubMed - as supplied by publisher]
Publication date: Available online 25 February 2020Source: Clinica Chimica ActaAuthor(s): Juan Zhou, Xinxin Zhang, Huifang Tang, Jia Yu, Xuyu Zu, Zhizhong Xie, Xiaoyan Yang, Juan Hu, Fang Tan, Qing Li, Xiaoyong Lei
Publication date: Available online 26 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Jin-Hui Zhu, R.A. De Mello, Qiu-Liang Yan, Jian-Wei Wang, Yan Chen, Qing-Huang Ye, Zhi-Jiang Wang, Hai-Jun Tang, Tao Huang
DISCUSSION: For a diagnosis of primary breast cancer of the vulva, a thorough metastatic workup should be performed, with attention directed toward detecting a breast primary disease by results of the history, physical examination, and radiologic examination of the breasts mainly to help confirm that the vulvar lesion is the primary site as opposed to metastasis from a breast primary cancer and also for staging. Management of this rare entity is challenging because of a lack of specific guidelines, and treatment, therefore, is similar to that of breast cancer.Treatment should consist of an individualized combination of sur...
Publication date: Available online 26 February 2020Source: Urology Case ReportsAuthor(s): Erdem Aktas, Murat Ucar, Bahar Akkaya, Erol Guntekin, Orkun Batmaz
CONCLUSION: In summary, circ-PRMT5 might play a key role in proliferation, migration, glycolysis of HCC cells via miR-188-5p/HK2 axis, which indicated that circ-PRMT5 might be a potential therapeutic target for HCC treatment. PMID: 32089501 [PubMed - as supplied by publisher]
Conclusion: The study showed that TET1 dysfunction inhibited the migration and invasion of BCPAP cells and might have a potential role in the pathogenesis of PTC. PMID: 32089682 [PubMed]
CONCLUSIONS: In summary, DLX6-AS1 promotes development and metastasis of ESCC by sponging miR-577 and could be a potential therapeutic target. PMID: 32096208 [PubMed - in process]
Authors: Miao H, Song WB, Zhu H, Wang Q, Tian Y Abstract OBJECTIVE: To investigate the effect of GREM1 on the sensitivity of cervical squamous carcinoma cells to radiotherapy and chemotherapy. PATIENTS AND METHODS: The resected cancer tissues and paracancerous tissues of patients with cervical carcinoma were collected. The expressions of GREM1 protein and mRNA in SiHa cell line of cervical squamous carcinoma were tested by Western blot and reverse transcription-polymerase chain reaction (qRT-PCR). The effect of GREM1 on chemotherapy sensitivity of SiHa cells was tested by MTT assay. SiHa cells were irradiated w...
CONCLUSIONS: TACE with CBATO is more effective and equally tolerant compared with cTACE in treating unresectable HCC patients. PMID: 32096197 [PubMed - in process]