Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months (VICI): a randomised, double-blind, placebo-controlled trial

Publication date: 25–31 January 2020Source: The Lancet, Volume 395, Issue 10220Author(s): Andrew Lotery, Sobha Sivaprasad, Abby O'Connell, Rosie A Harris, Lucy Culliford, Lucy Ellis, Angela Cree, Savita Madhusudhan, Francine Behar-Cohen, Usha Chakravarthy, Tunde Peto, Chris A Rogers, Barnaby C Reeves, Samir Bellani, Helen Griffiths, Suresh Thulasidharan, Catrin Watkins, Rebecca Kaye, Deepthy Menon, Qin NevilleSummaryBackgroundIn chronic central serous chorioretinopathy (CSCR), fluid accumulates in the subretinal space. CSCR is a common visually disabling condition that develops in individuals up to 60 years of age, and there is no definitive treatment. Previous research suggests the mineralocorticoid receptor antagonist, eplerenone, is effective for treating CSCR; however, this drug is not licensed for the treatment of patients with CSCR. We aimed to evaluate whether eplerenone was superior to placebo in terms of improving visual acuity in patients with chronic CSCR.MethodsThis randomised, double-blind, parallel-group, multicentre placebo-controlled trial was done at 22 hospitals in the UK. Participants were eligible if they were aged 18–60 years and had had treatment-naive CSCR for 4 months or more. Patients were randomly assigned (1:1) to either the eplerenone or the placebo group by a trial statistician through a password-protected system online. Allocation was stratified by best-corrected visual acuity (BCVA) and hospital. Patients were given either oral epler...
Source: The Lancet - Category: General Medicine Source Type: research

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AbstractThe Medina classification is the most widespread method to describe bifurcation lesions. However, little is known regarding its prognostic impact. Therefore, the aim of this study is to assess the prognostic significance of the Medina classification following percutaneous coronary intervention (PCI). From a prospective registry of 738 consecutive patients undergoing PCI for bifurcation lesions, 505 were treated with second-generation drug-eluting stents (DES). Of these, 407 (80.6%) presented with “true bifurcation” (TB) lesions (Medina class 1.0.1, 1.1.1, 0.1.1) and 98 (19.4%) in all other categories (&...
Source: Heart and Vessels - Category: Cardiology Source Type: research
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Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
Adding this ingredient to your diet could halve the risk of dying from a heart attack or stroke. → Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Heart Disease Source Type: blogs
Conclusion: The triple-staple technique is a safe alternative to the double-staple anastomosis after anterior resection. It also effectively shortens the operating time. PMID: 32054240 [PubMed - as supplied by publisher]
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
Listen to critics of the Wheat Belly lifestyle and you’d think that, by banishing all things wheat and grains from your life, you will be excommunicated from your church, tossed out of your club, ostracized by friends and family, and suffer dire health consequences like heart disease and colon cancer. After all, they say that you are eliminating an entire food group and will be crippled by lack of fiber and nutrients. Worse, our focus on increasing our intake of fats and oils will get you a heart attack, three stents, or bypass surgery and you’ll be obliged to take Lipitor and Repatha for a lifetime. First of a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle grain-free Weight Loss Source Type: blogs
. It saddens me: As popular as the Wheat Belly books and lifestyle have been, there are still millions of people who say things like “Oh, that Wheat Belly thing is just about being gluten-free.” They couldn’t be more wrong and have clearly not read any of the books. Yes, you can be gluten-free and consume foods that naturally have no gluten, gliadin, wheat germ agglutinin, amylopectin A, phytates, and the rest of the toxic components contained in wheat and related grains. You can eat apples, bacon, eggs, and salmon that are naturally gluten-free. You can drink water or tea that is gluten-free. No problems...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates gluten gluten-free grain-free grains wheat belly Source Type: blogs
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Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Fat grain-free low-carb saturated wheat belly Source Type: blogs
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Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
Both coronary artery disease (CAD) and diverticular disease (DD) are common in daily clinical practice. However, despite CAD and DD have been historically considered as two separate entities with a different pathophysiology, some studies have proposed a possible association between these diseases. In particular, this possible association has been suggested for the first time by Foster et al., which demonstrated a higher prevalence of acute myocardial infarction (AMI) among patients with DD [1]. Similar results have been confirmed by a recent Danish study, based on a population of about 80.000 patients which showed that DD ...
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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Source: JAHA:Journal of the American Heart Association - Category: Cardiology Authors: Tags: Epidemiology, Risk Factors, Health Services, Meta Analysis, Mortality/Survival Source Type: research
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