Chemotherapy and Inflammation Induced Damage of Intestinal Epithelium Is Associated with Increased T Cell Chemotaxis

Gastro-intestinal (GI) Graft-versus-Host Disease (GvHD) involves a complex interplay of conditioning-related injury and the pathologic immune response at the epithelial level. Enhanced tissue damage is a risk factor for GVHD. We demonstrated that donor T cell-derived IFN γ causes intestinal stem cell damage in GvHD. Recent studies have proposed that donor T cells directly interact with GI epithelium in GvHD in vivo, but the precise mechanisms remain incompletely understood. Here, we evaluate the influence of both cytokine- and chemotherapy-induced intestinal epithe lial damage on T cell migration and direct epithelial cell-T cell interactions using GI organoids as a model system.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Suze A. Jansen, Marliek van Hoesel, Michal Mokry, Leire Saiz Sierra, Shuichiro Takashima, Edward E. Nieuwenhuis, Alan M. Hanash, Caroline A. Lindemans Tags: 240 Source Type: research