Preventing Post-Transplant Diabetes Mellitus Via Orchestration of the IL-33/ST2 Axis in Pancreatic Islets

Post-transplant diabetes mellitus (PTDM) occurs after allogeneic hematopoietic cell transplantation (HCT) in over 50% of HCT recipients and will increase 3-fold their risk of death. Further, levels of soluble Stimulation-2 (ST2) are predictive of PTDM in adults and children. However, molecular pathology of PTDM remains poorly understood, and therapeutic strategies for PTDM are limited. PTDM is initiated by hyperinsulinemia and hyperglycemia, and the alarmin IL-33 has been found to contribute to the secretion of insulin in islets by activating innate lymphoid cells type 2 (ILC2s) via Stimulation2 (ST2), the IL-33 receptor (Dalmas E.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 244 Source Type: research