A Prospective Phase III Trial for Comparing Cyclophosphamide and Fludarabine Conditioning Regimen in Severe Idiopathic Aplastic Anemia

Our previous study showed that a less toxic regimen comprising reduced cyclophosphamide (Cy), fludarabine and anti-thymocyte globulin (ATG) (Cy-Flu-ATG), was less toxic for allogeneic hematopoietic cell transplantation (alloHCT) compared with standard Cy-ATG in patients with adult severe aplastic anemia (AA). We postulated that replacing Cy with Flu (Flu-ATG) would be more beneficial. Therefore, we performed a randomized phase III study to compare the regimen-related toxicities (RRTs) of two different conditioning regimens: Cy-ATG vs.

https://www.bbmt.org/article/S1083-8791(19)31067-5/fulltext?rss=yes

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Hawk Kim, Eunji Choi, Yunsuk Choi, Won-Sik Lee, Sung-Nam Lim, Yong Park, Hyeoung-Joon Kim, Chul Won Jung, Young Rok, Sukjoong Oh, Jinny Park, Je-Hwan Lee, Kyoo-Hyung Lee Tags: 372 Source Type: research