The Safety and Efficacy of Targeted Virus Specific Cytotoxic T-Lymphocytes (VST) Manufactured By the IFN-g Cytokine Capture System (CCS) for the Treatment of Refractory Adenovirus (ADV), Cytomegalovirus (CMV), Epstein Barr Virus (EBV) and BK Virus (BKV) in Children, Adolescents and Young Adults (CAYA) after Allogenic Hematopoietic Stem Cell Transplantation (Allo-HSCT), Solid Organ Transplantation (SOT), or with Primary Immunodeficiency (PID) (IND# 17449)

Viral infection remains a major cause of morbidity and mortality after allo-HSCT (Bollard/Heslop Blood 2016). Antibiotics for treatment of viral infection in immunocompromised patients are limited in efficacy and associated with toxicity (Gerdemann BBMT 2004; Sili Cytother 2012). Increasing evidence suggests that use of VST for immunocompromised patients with viral infections can provide therapeutic benefit and improve OS (Bollard/Heslop Blood 2016; Sutrave Cytother 2017). Methods of VST production include ex-vivo expansion and direct selection (Gottlieb Cytother 2017).

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Allyson Flower, Janet Ayello, Lauren Harrison, Erin Morris, Meghan Sturhahn, Elena Maryamchik, Yongping Wang, Lynn O'Donnell, Rolla Abu-Arja, Dean Lee, Julie-An M. Talano, Bryon D Johnson, Mitchell S. Cairo Tags: 95 Source Type: research