Stable to Improved Neurocognitive Outcomes in Children, Adolescents & Young Adults with High-Risk Sickle Cell Disease (SCD) Who Have Undergone Familial Haploidentical (FHI) Stem Cell Transplantation: A Prospective Study from Pre HSCT Period to 2 Years Post HSCT (IND 14359)

The cognitive and neurological impairments associated with SCD that are due to cerebral vascular injury have been well documented (DeBaun et al, Blood, 2012). Brain abnormalities are evident on neuroimaging and cognitive domains in the areas of attention, memory, processing speed, executive functioning, and lower general intellectual functioning. Processing speed in particular is a vulnerable domain, with deficits mediating difficulties across other domains and is independently decreased in SCD patients unrelated to overt or silent infarctions (Stotesbury et al, Neurology, 2018).

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Suzanne Braniecki, Theodore B. Moore, Julie-An M. Talano, Qiuhu Shi, Allyson Flower, Anne Panarella, Sandra Fabricatore, Erin Morris, Jordan Milner, Robert McKinstry, Shalini Shenoy, Mitchell S. Cairo Tags: 86 Source Type: research