Busulfan Pharmacokinetics Using 25% Adjusted Body Weight in Obese Stem Cell Transplant Patients

The use of adjusted body weight for dosing of conditioning chemotherapy is recommended in obese stem cell transplant (SCT) patients. Busulfan (Bu), specifically, has several acceptable dosing regimens per evidence based guidelines. We evaluated whether a 25% correction in dosing weight may underestimate the targeted area under the curve (AUC) for this narrow therapeutic agent.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Sila D Shalhoub, Breanna J Taylor, Katrina M Piedra, Amer Beitinjaneh, Shreya A Shah Tags: 612 Source Type: research