Outcomes in Children with Primary Immunodeficiencies Undergoing HSCT Complicated By BCG-Osis

BCG vaccination is an important global health measure in countries with endemic tuberculosis but poses significant risks when administered to patients with Severe Combined Immune Deficiency (SCID) or genetic defects associated with Mendelian Susceptibility to Mycobacterial Diseases (MSMD). A study by Marciano et al. reported that BCG-osis occurred in over 50% of BCG-vaccinated patients with SCID. The impact of this infection on allogeneic hematopoietic stem cell transplant (HSCT) outcomes is unclear.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 529 Source Type: research