Outcomes in Children with Primary Immunodeficiencies Undergoing HSCT Complicated By BCG-Osis
BCG vaccination is an important global health measure in countries with endemic tuberculosis but poses significant risks when administered to patients with Severe Combined Immune Deficiency (SCID) or genetic defects associated with Mendelian Susceptibility to Mycobacterial Diseases (MSMD). A study by Marciano et al. reported that BCG-osis occurred in over 50% of BCG-vaccinated patients with SCID. The impact of this infection on allogeneic hematopoietic stem cell transplant (HSCT) outcomes is unclear.
Background Streptococcus pneumonia is a significant cause of morbidity and mortality in adults who are immunocompromised and of advanced age. It is the standard of care to vaccinate all high-risk adults (18-64 years) and adults 65 years and older with 2 pneumococcal vaccines. However, pneumococcal immunization rates remain below the HealthyPeople2020 target goal of 90% nationally and locally.
Authors: Miller A, Cairns A, Richardson A, Lawrence J Abstract CONTEXT: Tuberculosis (TB) is a serious infectious disease with high rates of morbidity and mortality if left untreated. In Australia, TB has been virtually eradicated in non-Indigenous Australian-born populations but in remote Aboriginal and/or Torres Strait Islander communities TB presents a rare but significant public health issue. Remote health services are most likely to encounter patients with suspected and confirmed TB diagnosis but may be unprepared for supporting someone with this disease and the complexities of balancing public health risk wit...
Publication date: Available online 25 February 2020Source: Arthroscopy TechniquesAuthor(s): Matthew J. Craig, Travis G. Maak
A woman insisted she needed a liver transplant. But doctors wouldn't allow it, removing her from waiting lists and recommending treatment for alcohol addiction instead.
Publication date: March 2020Source: The Lancet Haematology, Volume 7, Issue 3Author(s): Kirsten M Williams, Jennifer Holter Chakrabarty
The drug maker said that in March it would begin two more clinical trials of remdesivir, an experimental antiviral drug, in more nations outside China.
ConclusionsThe clinical manifestations in these Mexican CGD patients were similar to those in patients elsewhere. This cohort is the largest in Latin America. Mycobacterial infections are an important cause of morbidity in Mexico, as in other countries in which tuberculosis is endemic and infants are vaccinated with BCG. X-linked CGD accounted for most of the cases in Mexico, as in other Latin American countries. However, a significant number ofCYBA andNCF2 mutations were identified, expanding the spectrum of known causal mutations.
ConclusionsSeveral PID entities are susceptible to BCG-VAC. Systemic neonatal PID screening programs may help to prevent a substantial amount of BCG vaccination complications.