KIR Genotype and KIR Ligand Phenotypes That Improve the in Vitro Cord Blood or Autologous NK Cell Mediated Cytotoxicity Against Myeloma Marrow Plasma Cells

Killer Immunoglobulin-like Receptor (KIR) inhibition is known to influence the cytotoxic effects of natural killer (NK) cells against cancer cells. KIRs can be protective against relapse in myeloma (MM) (Gabriel et al Blood 2010, Kr öger et al leukemia 2011) by NK cell licencing or through blocking of the inhibitory KIR receptors such as NKG2A (Mahaweni et al, 2018).
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 483 Source Type: research