Identification and Utilization of Pre-Search Killer Cell Immunoglobulin-Type Receptor (KIR) B(x) Unrelated Donors Improves the Selection of KIR Favorable Donors, the Transplant Coordinator Perspective

KIR B(x) haplotype donors have been reported to improve outcomes in patients (pts) receiving unrelated donors (URD) for myeloid malignancies, non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM). Donors are categorized as KIR “Best” or “Better”. Our center performs donor KIR genotyping and haplotype assignment routinely as part of our URD evaluation for pts undergoing transplantation for myeloid disorders, NHL and MM. When presented with multiple equivalently HLA matched URDs, our physicians will prioritize KIR B (X) donors over KIR A/A donors.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Barbara Adler-Brecher, Katayoon Modjarrad-Shaw, Angelica Panganiban, Dawn Wakefield, Claritza Sanabria, Maridel Tenned, Jacklyn Russo, Ann Ferolin-Ocot, Gabrielle Marczewski, Nancy Durning, Melanie Hankewycz, Elana Smilow, Jennifer A. Krajewski, Alfred P. Tags: 447 Source Type: research