Allogeneic Stem Cell Transplantation in Patients with Myelodysplastic Syndrome (MDS) Using Treosulfan Based Compared to Standard Reduced-Intensity or Myeloablative Conditioning Regimens. a Report of the Chronic Malignancies Working Party of EBMT

Allogeneic stem cell transplantation (SCT) is potentially curative therapy for patients with MDS. Prior studies have shown no overall-survival (OS) advantage of any conditioning regimen over the others. Reduced-intensity conditioning (RIC) is usually associated with lower non-relapse mortality (NRM) compared to myeloablative conditioning (MAC), however, relapse rates are higher, resulting in similar OS. Fludarabine and treosulfan (FT) is a reduced-toxicity regimen with intense anti leukemia activity in patients with myeloid malignancies.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Avichai Shimoni, Marie Robin, Simona Iacobelli, Anja van Biezen, Dietrich Wilhelm Beelen, Ghulam J. Mufti, Fabio Ciceri, Lothar Kanz, Liisa Volin, Didier Blaise, Arnold Ganser, Thomas Luft, Patrice Chevallier, Rainer Schwerdtfeger, Theo de Witte, Nicolaus Tags: 43 Source Type: research