A Retrospective Review of Referral Rates for Genetic Screening of AYA Patients Diagnosed with Myeloid Malignancies and Aplastic Anemia

Genetic abnormalities can predispose patients to develop acute myeloid leukemia (AML), aplastic anemia (AA) and myelodysplastic syndrome (MDS). These mutations are more often seen in pediatric patients so genetic screening is more routinely performed in that population. Recent algorithms propose screening in adolescent and young adults (AYAs) with AML/AA/MDS. However, this is not routine practice in community hospitals where most AYAs are treated. Discovery of familial genetic abnormalities can impact donor choice in patients undergoing allogeneic stem cell transplant and treatment/screening in family members.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 145 Source Type: research