Prospective Identification of Unrelated Donors with Low Inhibitory Donor KIR3DL1 – Recipient HLA-B Interaction Decreases Relapse and Improves Survival after Allogeneic Hematopoietic Cell Transplantation for Myeloid Neoplasia

Retrospective studies indicate that the use of unrelated hematopoietic stem cell donors with Killer Ig-like Receptor (KIR) genotypes resulting in low inhibitory interactions with recipient HLA are associated with lower relapse and higher survival in patients with myeloid neoplasia undergoing allogeneic hematopoietic cell transplantation (allo HCT). To validate these findings in a prospective fashion and to determine if advantageous KIR donors can readily be identified for patients with myeloid neoplasia, we prospectively KIR genotyped and provided KIR/HLA-based ranking for unrelated donors (URD) evaluated for patients with a diagnosis of acute myeloid leukemia or myelodysplastic syndrome undergoing workup at our center for allo HCT.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 172 Source Type: research