Defibrotide Modulates Pulmonary Endothelial Cell Activation and Protects Against Lung Inflammation in Pre-Clinical Models of LPS-Induced Lung Injury and Idiopathic Pneumonia Syndrome.

Pulmonary dysfunction remains one of the greatest challenges to the optimization of care following allogeneic blood and marrow transplantation (alloBMT). Almost half of the pneumonias that occur early after alloBMT are noninfectious, termed idiopathic pneumonia syndrome (IPS). Injury/activation to vascular endothelial cells (ECs) are believed to be directly related to several post-BMT complications, including IPS. Hence, identifying inflammatory mechanisms contributing to EC damage and strategies to protect EC integrity and function have significant merit.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Orly R. Klein, Sung Choi, Azeb Haile, Yiouli P. Ktena, Elizabeth Pierce, Megan Smith, Kenneth R. Cooke Tags: 197 Source Type: research