KD025 for Patients with Chronic Graft-Versus-Host Disease (cGVHD) – Long-Term Follow-up of a Phase 2a Study (KD025-208)

cGVHD exhibits both autoimmune and fibrotic features across multiple organ systems. KD025 is an orally available Rho-associated coiled-coil kinase 2 (ROCK2) selective inhibitor.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 275 Source Type: research

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In conclusion, PEGylation of antigenic peptides is an effective and feasible strategy to improve Treg-inducing, peptide-based vaccines with potential use for the treatment of autoimmune diseases, allergies, and transplant rejection.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
(University of Montreal) Developed in Canada, the UM171 molecule was used in a blood transplant by a Montreal medical team on a young man suffering from severe aplastic anemia, an autoimmune disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract The ovary serves as the source of oocytes for the maintenance of female fertility and is a major supplier of sex hormones for endocrine homeostasis. Various circumstances such as genetic defects, autoimmune disorders, natural aging and environmental toxins can damage the ovaries leading to diminished ovarian function, and there are currently no effective treatment regimens for such loss of function. Stem cells show promising for treating many refractory diseases, and stem cell transplantation has been shown to be effective and safe as a new therapeutic method for ovarian injuries and ovarian aging in both...
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research
Heart failure has been classified in many ways, with prevailing levels of our knowledge and ignorance. It is based on a variety of factors like rapidity of onset, etiology, chambers involved, hemodynamics, etc.  Forward vs backward failure Acute vs chronic failure RV/LV or Biventicular failure  Systolic vs diastolic heart failure High output vs low out failure Ischemic vs non-ischemic failure  Reversible vs Refractory HF  None of them have really helped at the bedside though it helped us understand the condition. Now, in the last decade, we have crash-landed on our favorite obsession to clas...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Uncategorized ase esc acc csi echo cariteria definition of heart failure diastolic heart failure ejection fraction limitation forward vs backward failure hf with normal GLS HFpEF HFrEF rv vs lv failure systolic vs diastolic heart failu Source Type: blogs
Regulatory T cells (Tregs) are crucial in maintaining tolerance. Hence, Treg immunotherapy is an attractive therapeutic option in autoimmune diseases and organ transplantations. Currently, autoimmune diseases do not have a curative treatment and transplant recipients require life-long immunosuppression to prevent graft rejection. There has been significant progress in understanding polyclonal and antigen-specific Treg biology over the last decade. Clinical trials with good manufacturing practice (GMP) Treg cells have demonstrated safety and early efficacy of Treg therapy. GMP Treg cells can also be tracked following infusi...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract The T-cell response is regulated by the balance between costimulatory and coinhibitory signals. Immune checkpoints are essential for efficient T-cell activation, but also for maintaining self-tolerance and protecting tissues from damage caused by the immune system, and for providing protective immunity. Modulating immune checkpoints can serve diametric goals, such that blocking a coinhibitory molecule can unleash anti-cancer immunity whereas stimulating the same molecule can reduce an over-reaction in autoimmune disease. The purpose of this review is to examine the regulation of T-cell costimulation and c...
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
Adult and pediatric gastroenterologists and hepatologists often manage patients who are at increased risk for infections as a consequence of their disease or because of their use of immunosuppressive agents. Important patient groups to consider include those with inflammatory bowel disease (IBD), autoimmune hepatitis, cirrhosis, and those after a liver transplant. When including patients older than the age of 65 and the 3% of the general population who are immunosuppressed, it is clear that a substantial number of patients seen in gastroenterology and hepatology practices are at increased risk for infection.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Here and Now: Clinical Practice Source Type: research
We present a case of BP in a 33-year-old man with history of bladder exstrophy from birth and renal transplantation from 5 years ago. There was no finding in favour of his disease was caused by graft rejection, drug usage, or viral infection. Therefore, BP could be an accidental finding in this patient with idiopathic aetiology. PMID: 32943598 [PubMed - in process]
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
Primary immunodeficiencies (PIDs) encompass a heterogeneous group of diseases affecting all components of the immune system 1. They are caused by mutations in various genes and may phenotypically present with infections, as well as with autoimmune phenomena and malignancies 2. Despite advances in gene therapy, allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative treatment for most children with various malignant or nonmalignant diseases, including selected PIDs.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
A large body of evidence indicates that MSCs have immune suppressive potentials. MSC transfer showed therapeutic effects against various autoimmune disorders and graft-versus-host diseases in preclinical and clinical settings, leading to a growing interest in their clinical use.1 MSCs express various immune suppressive molecules, TGF-beta, IL-10, indoleamine 2,3-dioxygenase, and prostaglandin E2, inhibiting immune cells and expanding or generating Tregs.2 However, the role of endogenous MSCs in immune regulation in vivo remains largely unclear.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
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