Regulation of breast cancer resistance protein and P ‐glycoprotein by ezrin, radixin and moesin in lung, intestinal and renal cancer cell lines

ConclusionsOur findings indicate that regulation of BCRP and P ‐gp functions by ERM proteins is organ‐specific. Thus, if the appropriate ERM protein(s) are functionally suppressed, accumulation of BCRP or P‐gp substrates in lung, intestine or kidney cancer tissue might be specifically increased.

Source: Journal of Pharmacy and Pharmacology - January 23, 2020 Category: Drugs & Pharmacology Authors: Kentaro Yano, Chiaki Okabe, Kenta Fujii, Yuko Kato, Takuo Ogihara Tags: Research Paper Source Type: research