Cancers, Vol. 12, Pages 285: Independent Evaluation of the Respective Predictive Values for High-Grade Prostate Cancer of Clinical Information and RNA Biomarkers after Upfront MRI and Image-Guided Biopsies
Cancers, Vol. 12, Pages 285: Independent Evaluation of the Respective Predictive Values for High-Grade Prostate Cancer of Clinical Information and RNA Biomarkers after Upfront MRI and Image-Guided Biopsies Cancers doi: 10.3390/cancers12020285 Authors: Roumiguié Ploussard Nogueira Bruguière Meyrignac Lesourd Péricart Malavaud Upfront MRI is taking the lead in the diagnosis of clinically significant prostate cancer, while few image-guided biopsies (IGBs) fail to demonstrate clinically significant prostate cancer. The added value of innovative biomarkers is not confirmed in this context. We analysed SelectMDx-v2 (MDx-2) in a cohort of upfront MRI and image-guided biopsy patients. Participants included patients who received a trans-rectal elastic-fusion registration IGB on the basis of DRE, PSA, PCA3, and PCPT-2.0 risk evaluation. Pre-biopsy MRI DICOM archives were reviewed according to PI-RADS-v2. Post-massage first-void urine samples stored in the institutional registered bio-repository were commercially addressed to MDxHealth to obtain MDx-2 scores. Univariate and multivariate analyses were conducted with the detection on IGB of high-grade (ISUP 2 and higher) as the dependent variable. High-grade cancer was demonstrated in 32/117 (27.4%) patients (8/2010–8/2018). Age, prostate volume, biopsy history, MDx-2, and PI-RADS-v2 scores significantly related to the detection of high-grade cancer. MDx-2 scores and the clinica...
Conditions: Prostate Cancer; Treatment Interventions: Procedure: Focal therapy(Irreversible Electroporation); Procedure: Radical prostatectomy Sponsor: Shanghai East Hospital Not yet recruiting
This study aimed to evaluate whether IRE combining indoleamine 2,3-dioxygenase inhibitor (IDOi, Epacadostat) loaded iron oxide nanocarriers (IDOi-INCs) can serve as a magnetic resonance imaging (MRI) –guided local ablation strategy for enhancing prostate cancer immunotherapy.
The purpose of this study is to assess clinical outcomes of prostatic artery embolization (PAE) in men with localized prostate cancer (PCa) and lower urinary tract symptoms (LUTS) from benign prostatic hyperplasia (BPH).
We aimed to update the diagnostic yield of in-bore 3Tesla magnetic-resonance-guided biopsy (3T-MRGB) for prostate cancer (PCa) detection based on the assessment by recently described Prostate Imaging Reporting and Data System version 2.1(PIRADSv2.1).
We report 12-month outcomes from the TULSA-PRO Ablation Clinical Trial (TACT) pivotal study.
To evaluate the changes of 3 Tesla (3T) mpMRI and prostate-specific antigen (PSA) parameters before and during multiple time points after whole gland prostate cancer (PCa) treatment using MRI-guided directional transurethral ultrasound ablation (TULSA)
Focal laser ablation (FLA) for prostate cancer is usually performed in an MRI gantry, but can be performed outside MRI with transrectal ultrasound (TRUS) –MRI fusion. Relative costs were compared between the two approaches.
To evaluate the potential of sequential MR image –guided local immune checkpoint blockade immunotherapy using multifunctional carriers after a prechemotherapy in prostate cancer (PC).
For localized prostate cancer, a hypofractionated radiotherapy regimen that cuts treatment time in half continues to have noninferior efficacy long-term relative to a conventional radiotherapy regimen.Medscape Medical News
Publication date: Available online 20 February 2020Source: International Journal of PharmaceuticsAuthor(s): Xiao Wu, Athena Kasselouri, Juliette Vergnaud-Gauduchon, Véronique RosilioAbstractBeta-lapachone (β-Lap) is an anticancer drug activated by the NAD(P)H quinone acceptor oxidoreductase (quinone) (NQO1), an enzyme over-expressed in a large variety of tumors. B-Lap is poorly soluble in water and in most biocompatible solvents. Micellar systems, liposomes and cyclodextrins (CDs) have been proposed for its solubilization. In this work, we analyzed the properties and in vitro efficacy of β-Lap loaded in po...