99mTC-Sestamibi Breast Imaging: Current Status, New ideas and Future Perspectives

Publication date: Available online 23 January 2020Source: Seminars in Cancer BiologyAuthor(s): Nicoletta Urbano, Manuel Scimeca, Virginia Tancredi, Elena Bonanno, Orazio SchillaciAbstractHere we proposed the most recent innovations in the use of Breast Specific Gamma Imaging with 99mTc-sestamibi for the management of breast cancer patients. To this end, we reported the recent discoveries concerning: a) the implementation of both instrumental devices and software, b) the biological mechanisms involved in the 99mTc-sestamibi uptake in breast cancer cells, c) the evaluation of Breast Specific Gamma Imaging with 99mTc-sestamibi as predictive markers of metastatic diseases. In this last case, we also reported preliminary data about the capability of Breast Specific Gamma Imaging with 99mTc-sestamibi to identify breast cancer lesions with high propensity to form bone metastatic lesions due to the presence of Breast Osteoblast-Like Cells.
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research